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  • Title: Long-term feeding a high-fat diet causes histological and parasitological effects on murine schistosomiasis mansoni outcome.
    Author: Neves RH, Miranda de Barros Alencar AC, Costa-Silva M, Aguila MB, Mandarim-de-Lacerda CA, Machado-Silva JR, Gomes DC.
    Journal: Exp Parasitol; 2007 Apr; 115(4):324-32. PubMed ID: 17112519.
    Abstract:
    This study investigated whether long-term feeding a high-fat diet (HFC) has an effect on schistosomiasis mansoni outcome compared to standard chow diet (SC). Swiss Webster female mice (3 wk old) fed each diet over 5 months, and then were infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring growth rates twice a week and measuring serum levels of lipoproteins. Mice were euthanised 63 days after infection. Parasitological and liver histological analyses were performed. The levels of TC, HDL-C and LDL-C, fecal and tissue schistosome eggs were statistically different (p<0.05) between groups. Livers from HFC mice showed exudative, exudative/exudative-productive, exudative-productive and productive granulomas, some degree of hepatic steatosis and focal necrosis. Mice fed normal-chow did not present productive granulomas and hepatic steatosis. The morphometric evaluation of hepatic granulomas did not reach statistical significance (p>0.05) between diets assayed. The high-fat diet for long-term produces effects on schistosomiasis mansoni outcome.
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