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  • Title: Does ketotifen act by directly stimulating beta-adrenergic system?
    Author: Castillo JG, Santos F, Aguila R, Oehling A.
    Journal: Allergol Immunopathol (Madr); 1990; 18(5):249-54. PubMed ID: 1711281.
    Abstract:
    Through this study we proved that the inhibitory effect ketotifen has on antigen-specific histamine release (ASHR) does not have any relation with beta-adrenergic system stimulation. However, it increases the inhibitory effect of histamine release caused by isoproterenol. Therefore, although ketotifen does not directly stimulate beta-adrenergic receptors to inhibit mediator secretion, its action correlates with the response produced through the stimulation of these receptors.
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