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  • Title: p16(INK4a) promoter hypermethylation in oral scrapings of oral squamous cell carcinoma risk patients.
    Author: Ruesga MT, Acha-Sagredo A, Rodríguez MJ, Aguirregaviria JI, Videgain J, Rodríguez C, de Pancorbo Mde L, Aguirre JM.
    Journal: Cancer Lett; 2007 May 18; 250(1):140-5. PubMed ID: 17113222.
    Abstract:
    Aberrant promoter hypermethylation is common in oral squamous cell carcinoma (OSCC) and may be useful as a marker for cancer cells. The aim of our study was to assess whether the detection of hypermethylation of the promoter region of p16(INK4a) in oral cytological samples could be a marker in patients with risk of developing an OSCC. Hypermethylation was detected in 20% (29/145) of the cases analyzed. These findings provide further evidence that the inactivation of p16(INK4a), due to methylation, is an early event in the carcinogenic pathway of OSCC.
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