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  • Title: Dissecting the coupling between the voltage sensor and pore domains.
    Author: Roux B.
    Journal: Neuron; 2006 Nov 22; 52(4):568-9. PubMed ID: 17114039.
    Abstract:
    The gating mechanism of K(v) channels is not known. In this issue of Neuron, Soler-Llavina et al. present fascinating results that support the concept of relatively independent voltage-sensing modules. However, they also find that its interactions with the pore domain are rather complex, with specific S4-S5 intersubunit contacts underlying the concerted transition leading to the channel opening.
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