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  • Title: Maps, codes, and sequence elements: can we predict the protein output from an alternatively spliced locus?
    Author: Sharma S, Black DL.
    Journal: Neuron; 2006 Nov 22; 52(4):574-6. PubMed ID: 17114042.
    Abstract:
    Alternative splicing choices are governed by splicing regulatory protein interactions with splicing silencer and enhancer elements present in the pre-mRNA. However, the prediction of these choices from genomic sequence is difficult, in part because the regulators can act as either enhancers or silencers. A recent study describes how for a particular neuronal splicing regulatory protein, Nova, the location of its binding sites is highly predictive of the protein's effect on an exon's splicing.
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