These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ultraviolet light-induced and green light-induced transient pupillary light reflex in mice.
    Author: Yao G, Zhang K, Bellassai M, Chang B, Lei B.
    Journal: Curr Eye Res; 2006 Nov; 31(11):925-33. PubMed ID: 17114118.
    Abstract:
    PURPOSE: To study UV light-induced and green light-induced pupillary light reflex (PLR) in mice and to measure the illumination thresholds of rod-mediated and cone-mediated PLR responses. METHODS: We measured dark-adapted transient PLR- in C57BL/6 mice elicited with ultraviolet and green light over an intensity range of 9 log units. To assist in isolating the responses mediated by rods and cones, we studied the PLRs in mouse models presenting pure cone and pure rod functions. We also characterized ERG signals in these mice under the same experimental conditions. RESULTS: The UV light-induced transient PLR has identical intensity-response curves as green light-induced PLR in all the three mice strains. The threshold (5% PLR) of rod-driven PLR is 107 approximately 108 photons cm2 s-1, which is 1 approximately 2 log units lower than the dark-adapted ERG b-wave. The threshold of cone-driven PLR is approximately 1012.5 photons cm-2 s-1 and is similar to that of the cone ERG. CONCLUSIONS: We demonstrated that mice have PLR responses under UV stimulation. The cone-elicited PLRs have a threshold that is approximately 5 log units higher than that of rod-elicited PLR at both UV and green wavelengths. We observed a divergence between the spectra responses in PLR and ERG. However, the mechanism and implications of this phenomenon are yet to be identified.
    [Abstract] [Full Text] [Related] [New Search]