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  • Title: [The characteristics of the sodium currents across EGTA-modified calcium channels in the membrane of cultured rat cardiomyocytes].
    Author: Verkhratskiĭ AN, Pronchuk NF, Savchenko AN.
    Journal: Fiziol Zh (1978); 1991; 37(2):49-53. PubMed ID: 1711483.
    Abstract:
    In isolated, cultured neonatal rat ventricular myocytes sodium currents through calcium channels induced by lowering of extracellular calcium concentration 100 nmol/l have been investigated by whole-cell patch clamp technique. Such Na(+)-carried currents are modulated by classic Ca2+ agonists and antagonists. The potential-dependent characteristics of Na+ current are shifted at 20 mV in hyperpolarizing direction as compared to initial Ca(2+)-carried current. The inactivation decay of Na+ current through Ca2+ channels has the monoexponential behaviour. The possible action of extracellular Ca2+ lowering on Ca2+ channel selective filter and gating mechanisms is suggested.
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