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  • Title: Hereditary diabetes insipidus: an immunohistochemical study of the hypothalamus and pituitary gland.
    Author: Bergeron C, Kovacs K, Ezrin C, Mizzen C.
    Journal: Acta Neuropathol; 1991; 81(3):345-8. PubMed ID: 1711761.
    Abstract:
    We report the histological findings in a case of hereditary diabetes insipidus (HDI) using vasopressin (VP) immunohistochemistry. The hypothalamus displayed a marked loss of magnocellular VP neurons, with preservation of the smaller cells. The neurohypophysis was severely atrophic with scanty immunoreactivity. Our results support the hypothesis that HDI results from a selective degeneration of VP neurons affecting chiefly the magnocellular elements projecting to the neurohypophysis. The sparing of the parvocellular component may reflect the projection of these neurons to non-pituitary targets.
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