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  • Title: Cloning and characterization of bovine insulin-like growth factor binding protein-3 (bIGFBP-3).
    Author: Spratt SK, Tatsuno GP, Sommer A.
    Journal: Biochem Biophys Res Commun; 1991 Jun 28; 177(3):1025-32. PubMed ID: 1711841.
    Abstract:
    We report for the first time the isolation of a cDNA encoding the complete amino acid sequence for bovine growth hormone-dependent insulin-like growth factor binding protein-3 (bIGFBP-3). The deduced amino acid sequence from the cDNA revealed a mature polypeptide consisting of 264 amino acids and a 27 amino acid putative signal peptide. The amino acid sequence is over 80% homologous with human IGFBP-3 with complete conservation of the 18 cysteine residues and the 3 Asn-linked glycosylation sites. Between the two species there are 44 amino acid substitutions. Northern analysis of the bIGFBP-3 mRNA in bovine tissue revealed a single mRNA species of 1.65 kilobases.
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