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  • Title: Poloxamer 188 failed to prevent exercise-induced membrane breakdown in mdx skeletal muscle fibers.
    Author: Quinlan JG, Wong BL, Niemeier RT, McCullough AS, Levin L, Emanuele M.
    Journal: Neuromuscul Disord; 2006 Dec; 16(12):855-64. PubMed ID: 17118658.
    Abstract:
    We sought to determine the effectiveness of poloxamer 188 (P188) in protecting dystrophin-deficient, mdx skeletal muscle fiber membrane against exercise-induced breaches. mdx mice were treated with either P188 or placebo via intraperitoneal injections and run on a treadmill for 60-90 min. Membrane breakdown was quantified in cross-sections of rectus femoris muscle pretreated with Evans blue dye (in vivo). The mean % dye-penetrated muscle in the P188 and placebo groups was not significantly different in each of three trials. These results contrast with a recent report of P188 being highly effective in protecting the stretch- and dobutamine-stressed mdx heart muscle. The most likely explanations for the disparity are: (1) the exercise stress we used was beyond the protective range of P188, (2) P188 delivery and serum concentration were sub-optimal, or (3) the mdx skeletal myopathy and cardiomyopathy have fundamentally different responses to treatment.
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