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  • Title: Oxygen transfer model in recombinant Pichia pastoris and its application in biomass estimation.
    Author: Liang J, Yuan J.
    Journal: Biotechnol Lett; 2007 Jan; 29(1):27-35. PubMed ID: 17120095.
    Abstract:
    An oxygen transfer model was established for Pichia pastoris growing on glycerol and methanol in a stirred tank bioreactor and expressing a recombinant human serum albumin (rHSA). This was based on pseudo-steady state mass balance, where the volumetric O(2) transfer coefficient, k (L) a, was estimated as a function of power input per unit volume and aeration rate. Under pseudo-steady state, the O(2) transfer rate model matched the O(2) uptake rate obtained from a previous macrokinetic model. This procedure was also applied to estimate biomass concentration by using the on-line rolling identification approach.
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