These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The safety and efficacy of sertaconazole nitrate cream 2% for tinea pedis.
    Author: Savin R, Jorizzo J.
    Journal: Cutis; 2006 Oct; 78(4):268-74. PubMed ID: 17121064.
    Abstract:
    To determine the safety and efficacy of topical sertaconazole nitrate cream 2% in the treatment of tinea pedis, 2 randomized, multicenter, double-blinded, parallel group, vehicle-controlled studies were conducted. A total of 588 subjects were enrolled, and 383 subjects were randomized to treatment with sertaconazole or vehicle applied twice daily for 4 weeks. Improvements in symptoms were noted at week 1 in the active treatment group. At week 4, mycologic cure was seen in 70.3% of sertaconazole-treated subjects and 36.7% of vehicle-treated subjects (P<.0001). At week 6, 46.7% of sertaconazole-treated subjects had successful treatment outcomes compared with 14.9% of vehicle-treated subjects (P<.0001). No serious adverse events were reported, and rates of cutaneous adverse events were comparable between treatment groups. In conclusion, sertaconazole nitrate cream 2% was well-tolerated, offered rapid relief of symptoms, and achieved high rates of mycologic cure. The stability of the mycologic cure rates through weeks 5 and 6 (2 weeks after cessation of therapy) indicate that sertaconazole protects against reinfection.
    [Abstract] [Full Text] [Related] [New Search]