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  • Title: [Mechanisms of the anticoagulation activity of new semi-synthetic heparinoids].
    Author: Azarova LA, Siatkovskiĭ VA, Kaputskiĭ FN, Torgashov VI.
    Journal: Gematol Transfuziol; 1991 Apr; 36(4):23-5. PubMed ID: 1712331.
    Abstract:
    Compounds representing chemically modified derivatives of natural polysaccharides and possessing heparin-like properties have been obtained basing on new methods of sulphatization++ of hydroxyl-containing polymers. The study of the anticoagulation activity of mannan, starch, dextran sulfates permits a suggestion that these compounds realize their anticoagulant potential not through antithrombin-III. A relationship has been established between the properties of semi-synthetic heparinoids and sulfur percentage, molecular mass and the type of polymeric matrix. The investigations conducted have made possible the development of effective thrombosis-preventing drugs and further thorough study of their effects.
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