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  • Title: The effect of alpha1-24-corticotropin on growth hormone release in prepubertal children.
    Author: Caccamo A, Garlaschi C, di Natale B, del Guercio MJ, Chiumello G.
    Journal: Helv Paediatr Acta; 1975 Oct; 30(3):241-5. PubMed ID: 171239.
    Abstract:
    The effect of alpha1-24-corticotropin-Zn on the results of pituitary stimulation tests (moderate standardized physical exercise, arginine infusion, insulin-induced hypoglycemia) was studied in 27 prepubertal children with non-endocrine retardation of growth and development. After administration of 1 mg alpha1-24-corticotropin, the basal blood glucose and plasma cortisol levels rose significantly. However, the growth hormone increase after the three stimulation tests was significantly lower than without the corticotropin injection. The results demonstrate the inhibiting effect of alpha1-24-corticotropin on growth hormone secretion.
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