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  • Title: Progress and obstacles in the development of an AIDS vaccine.
    Author: Letvin NL.
    Journal: Nat Rev Immunol; 2006 Dec; 6(12):930-9. PubMed ID: 17124514.
    Abstract:
    Recent experimental observations suggest approaches to immunization that might finally result in at least a partially effective vaccine against infection with HIV-1. In particular, advances in our understanding of the contribution of vaccine-elicited cellular immunity to protecting memory CD4(+) T cells from virus-mediated destruction provide rational strategies for the development of this vaccine. This is therefore an ideal time to review our current understanding of HIV-1 and its control by the immune system, as well as the remaining problems that must be solved to facilitate the development of an effective vaccine against AIDS.
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