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  • Title: Infection and musculoskeletal conditions: Lyme borreliosis.
    Author: Schnarr S, Franz JK, Krause A, Zeidler H.
    Journal: Best Pract Res Clin Rheumatol; 2006 Dec; 20(6):1099-118. PubMed ID: 17127199.
    Abstract:
    Lyme borreliosis is a tick-borne infectious disease caused by the spirochaetes Borrelia burgdorferi, B. garinii and B. afzelii. It comprises a wide spectrum of symptoms affecting skin, musculoskeletal system, heart, eyes, central and peripheral nervous system. The diagnosis is based on clinical findings in combination with detection of specific IgM and/or IgG antibodies. Diagnostic problems arise from patients with non-specific symptoms and positive IgG antibody detection. Adequate antibiotic therapy cures more than 90% of the patients. However, in some patients repeated therapy is necessary and a small number of patients develop chronic arthritis or other features. While there is currently no vaccine available, prevention of tick bite is the most effective prophylaxis.
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