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  • Title: Buprenorphine in long-term control of chronic pain in cancer patients.
    Author: Pace MC, Passavanti MB, Grella E, Mazzariello L, Maisto M, Barbarisi M, Baccari E, Sansone P, Aurilio C.
    Journal: Front Biosci; 2007 Jan 01; 12():1291-9. PubMed ID: 17127381.
    Abstract:
    The aim of this randomized open-label prospective study was to evaluate the analgesic activity of buprenorphine in a transdermal formulation for cancer chronic pain control versus sustained-release morphine, in all cases combined with oral tramadol. A transdermal system with 35 microg/h buprenorphine was applied to the first group of patients (BT); the second group received 60 mg/day of sustained-release morphine (MT). In both groups oral tramadol was administered to a maximum of 200 mg daily, in case of need. The administration of transdermal buprenorphine versus morphine resulted in significant differences in the physical pain (P = 0.01), mental health (P = 0.03) and vitality (P = 0.001). These data indicated that the BT group showed an improvement of pain and a positive effect on the quality life.
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