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  • Title: [Adverse neurotoxic reactions of chemotherapy for tuberculosis and their treatment].
    Author: Lysov AV, Mordyk AV, Zatvornitskiĭ VA, Kondria AV.
    Journal: Probl Tuberk Bolezn Legk; 2006; (9):45-8. PubMed ID: 17128801.
    Abstract:
    A hundred and sixty-five first detected patients with pulmonary tuberculosis, receiving routine chemotherapy regimens were followed up for 4 months. Neurotoxic reactions of the central and peripheral nervous systems, which required isoniasid discontinuation, were developed in 13.3 and 11.5% of the patients, respectively. Therapy for neurotoxic reactions used cortexin in the study group (n = 22) and gamma or vitamins B in combination with glutaminic acid in the control group (n = 19). Cortexin used in the therapy of neurotoxic reactions produced a beneficial effect and permitted 90.9% of the patients to continue to use isoniazid while 42.2% of the controls resumed using isoniazid.
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