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  • Title: [A pregnant woman with nephrotic syndrome and focal segmental lesions].
    Author: Wada T, Nagaoka Y, Matsumoto H, Okada T, Han M, Yoshino M, Iwasawa H, Tomaru R, Uchinaga A, Ake T, Nakao T, Nagao T.
    Journal: Nihon Jinzo Gakkai Shi; 2006; 48(7):680-4. PubMed ID: 17128886.
    Abstract:
    A 32-year-old woman was admitted at 36 weeks' gestation because of increasing proteinuria and generalized edema. At the time of admission, serum creatinine was 1.3 mg/dl, and urinalysis demonstrated 4+ protein and 2+ occult blood. During her pregnancy, her blood pressure had been in the normal range. A normal healthy female neonate was delivered by caesarean section at 38 weeks' gestation. After delivery, the woman's 24-hour urine protein excretion was 11 g/day and serum albumin was 1.4 g/dl , hence nephrotic syndrome was diagnosed. Eleven days after delivery, a renal biopsy showed focal segmental lesions with glomerular epithelial cell injury. She was given 50 mg/day prednisolone and after a month, her 24-hour urinary protein excretion decreased to 2 g/day. One year later, she achieved complete remission. Although she had a relapse of nephrotic syndrome after twenty-one months, steroid therapy again achieved a good response.
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