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  • Title: Efficacy of carbamazepine and valproate as monotherapy for early epilepsy and single seizures.
    Author: Marson AG, Williamson PR, Taylor S, Maguire M, Chadwick DW.
    Journal: Neurology; 2006 Nov 28; 67(10):1872-5. PubMed ID: 17130429.
    Abstract:
    In the Multi-Centre Study of Early Epilepsy and Single Seizures (MESS), patients were randomly allocated to immediate or delayed antiepileptic drug treatment. For time to first seizure recurrence, MESS provides strong evidence of an effect for carbamazepine as monotherapy but mixed evidence of an effect for valproate.
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