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  • Title: Effects of lindane on fluidity and lipid composition in rat renal cortex membranes.
    Author: Pérez-Albarsanz MA, López-Aparicio P, Senar S, Recio MN.
    Journal: Biochim Biophys Acta; 1991 Jul 22; 1066(2):124-30. PubMed ID: 1713062.
    Abstract:
    The influence of lindane upon dynamic properties of plasma membranes from rat renal cortex has been investigated using a fluorescence polarization technique. Preincubation with lindane increased membrane fluidity in a manner that is dose-dependent. This increase was higher in brush border membranes than in basolateral membranes. However, a significant decrease of the membrane fluidity was found in brush border membranes when rats were injected with lindane for 12 days. A possible solution to this difference could involve a resistance to membrane disordering by lindane through a regulatory mechanism that would balance the amount of cholesterol and phospholipid classes in the renal cortex membranes of lindane-injected rats.
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