These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Enantioselective conjugate addition of a lithium ester enolate catalyzed by chiral lithium amides.
    Author: Duguet N, Harrison-Marchand A, Maddaluno J, Tomioka K.
    Journal: Org Lett; 2006 Dec 07; 8(25):5745-8. PubMed ID: 17134262.
    Abstract:
    Mixed aggregates of chiral lithium amide and lithium ester enolate have been employed in the enantioselective conjugate addition on alpha,beta-unsaturated esters. Michael adducts were obtained in ee's up to 76% combining a lithium enolate and a chiral 3-aminopyrrolidine lithium amide. The sense of the induction was found to be determined by both the relative configuration of the stereogenic centers borne by the amide and the solvent in which the reaction was conducted. [reaction: see text]
    [Abstract] [Full Text] [Related] [New Search]