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  • Title: A new antifungal macrolide, eushearilide, isolated from Eupenicillium shearii.
    Author: Hosoe T, Fukushima K, Takizawa K, Itabashi T, Kawahara N, Vidotto V, Kawai K.
    Journal: J Antibiot (Tokyo); 2006 Sep; 59(9):597-600. PubMed ID: 17136892.
    Abstract:
    In screening for antifungal substances, a new macrolide, eushearilide (1), was isolated from Eupenicillium shearii IFM54447. The structure of 1 was established to be 24-membered macrolide having a non-conjugated diene and a choline phosphate ester moetiy on the basis of detailed investigation of NMR, UV, IR and MS spectral data. Compound 1 showed antifungal activity against various fungi and yeasts, including human pathogens Aspergillus fumigatus, Trichophyton spp. and Candida spp.
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