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  • Title: G protein signaling in yeast: new components, new connections, new compartments.
    Author: Slessareva JE, Dohlman HG.
    Journal: Science; 2006 Dec 01; 314(5804):1412-3. PubMed ID: 17138892.
    Abstract:
    Signaling by cell surface receptors and heterotrimeric guanine nucleotide-binding proteins (G proteins) is one of the most exhaustively studied processes in the cell but remains a major focus of molecular pharmacology research. The pheromone-response system in yeast (see the Connections Map at Science's Signal Transduction Knowledge Environment) has provided numerous major advances in our understanding of G protein signaling and regulation. However, the basic features of this prototypical pathway have remained largely unchanged since the mid-1990s. New tools available in yeast are beginning to uncover new pathway components and interactions and have revealed signaling in unexpected locations within the cell.
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