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  • Title: [Voltage-gated calcium channels].
    Author: Kamkin AG, Kiseleva IS, Kirishchuk SI, Lozinskiĭ IT.
    Journal: Usp Fiziol Nauk; 2006; 37(4):3-33. PubMed ID: 17139998.
    Abstract:
    The article concentrates on representatives of voltage-gated calcium ion channels that are present in practically all cells. Regarded is the molecular arrangement of a voltage-gated calcium channel that consists of pore forming trans-membrane alpha1 subunit and auxiliary alpha2delta-, beta-, and gamma-subunits. Under discussion are the structure and functions of each subunit. The principles of subunits interaction are considered. The research represents modern classification of voltage-gated calcium channels, draws parallels with the earlier classifications and discusses calcium currents going through various calcium channels. Considered are the problems of regulating the activity of voltage-gated channels by proteinkinases. The issues of blockers and activators of voltage-gated calcium channels are brought up. The article gives a detailed analysis of the mechanisms of voltage-gated calcium channels selectivity. The molecular organization of the selectivity filter is considered. Presented are the basic theories of permeability of voltage-gated calcium channels.
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