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  • Title: Fat uses a TOLL-road to connect inflammation and diabetes.
    Author: Kim JK.
    Journal: Cell Metab; 2006 Dec; 4(6):417-9. PubMed ID: 17141623.
    Abstract:
    The link between inflammation and diabetes is well established, but the nature of the link is unresolved. Obesity, inflammation, and insulin resistance are major characteristics of diabetes. A study by Flier and colleagues () identifies Toll-like receptor 4 signaling activated by fatty acids as part of that link. This receptor mediates inflammatory events and insulin resistance in peripheral organs.
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