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  • Title: Poly(amino acid)s: promising enzymatically degradable stealth coatings for liposomes.
    Author: Romberg B, Metselaar JM, Baranyi L, Snel CJ, Bünger R, Hennink WE, Szebeni J, Storm G.
    Journal: Int J Pharm; 2007 Mar 01; 331(2):186-9. PubMed ID: 17145145.
    Abstract:
    Poly(amino acid)s (PAAs) were evaluated as coating polymers for long-circulating liposomes. The pharmacokinetics of PAA-coated liposomes were assessed in rats. Prolonged circulation times were obtained, comparable to those reported for poly(ethylene glycol) (PEG)-liposomes. Besides, the enzymatic degradability of PAAs was studied. PAAs - in free as well as liposome-associated form - are degradable by proteases, which is beneficial for reducing the risks of accumulation in vivo. Furthermore, complement activation by PAA-liposomes was evaluated in vitro and in vivo. Like other liposome types, they appear to activate the complement system. However, a role of endotoxin contamination of the PAA-liposome formulations used cannot be excluded in our complement activation studies.
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