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  • Title: Elevated levels of c-jun and c-fos transcripts in the aged rat liver.
    Author: Fujita T, Maruyama N.
    Journal: Biochem Biophys Res Commun; 1991 Aug 15; 178(3):1485-91. PubMed ID: 1714724.
    Abstract:
    Age-associated increases of transcript levels of several genes were studied using aged rat liver. Northern hybridization showed marked increases of c-jun, c-fos, and glutathione S-transferase P (GST-P) in 24-month-old rats. These genes have the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-responsive element called TRE in their structures. Thus, TRE seems to be involved in important age-associated changes of gene expression.
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