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  • Title: LdCompare: rapid computation of single- and multiple-marker r2 and genetic coverage.
    Author: Hao K, Di X, Cawley S.
    Journal: Bioinformatics; 2007 Jan 15; 23(2):252-4. PubMed ID: 17148510.
    Abstract:
    UNLABELLED: The scale of genetic-variation datasets has increased enormously and the linkage equilibrium (LD) structure of these polymorphisms, particularly in whole-genome association studies, is of great interest. The significant computational complexity of calculating single- and multiple-marker correlations at a genome-wide scale remains challenging. We have developed a program that efficiently characterizes whole-genome LD structure on large number of SNPs in terms of single- and multiple-marker correlations. AVAILABILITY: LdCompare is licensed under the GNU General Public License (GPL). Source code, documentation, testing datasets and precompiled executables are available for download at: http://www.affymetrix.com/support/developer/tools/devnettools.affx
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