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  • Title: Intravaginal administration of an inactivated vaccine prevents lesions induced by caprine herpesvirus-1 in goats.
    Author: Camero M, Bellacicco AL, Tarsitano E, Decaro N, Martella V, Tempesta M, Buonavoglia C.
    Journal: Vaccine; 2007 Feb 19; 25(9):1658-61. PubMed ID: 17150288.
    Abstract:
    To evaluate the efficacy of mucosal vaccination with a beta-propiolactone inactivated caprine herpesvirus-1 (CpHV-1) vaccine, goats received vaginal administrations of two 7-day cycles at 2 weeks intervals. Seven days after the end of the second cycle, goats were challenged intravaginally with 4 ml of virulent BA.1 strain of CpHV-1. Vaccinated goats shed challenge virus for 8 days but, in comparison with control unvaccinated-challenged goats, were significantly protected from the classical clinical signs of genital lesions. Even without adjuvants, prolonged mucosal vaccination induced production of secretory IgA and provided significant clinical protection.
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