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  • Title: Design of sensing ribonucleopeptides for small ligands.
    Author: Hagihara M, Hasegawa T, Tanabe Y, Sato S, Yoshikawa S, Ohkubo K, Morii T.
    Journal: Nucleic Acids Symp Ser (Oxf); 2004; (48):33-4. PubMed ID: 17150464.
    Abstract:
    Here we report a simple method to convert synthetic receptors to fluorescent sensors. An RNA-peptide complex (ribonucleopeptide) with a known three-dimensional structure is used as a framework of the receptor. Artificial ribonucleopeptide sensors were created with a combination of in vitro selection method and successive modification of the peptide with a fluorophore. A ribonucleopeptide complex of the fluorophore labeled peptide showed a remarkable fluorescence emission change upon binding cognate ligands.
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