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  • Title: Base-discriminating fluorescent DNA probe based on the guanine-specific fluorescence quenching.
    Author: Dohno C, Saito I.
    Journal: Nucleic Acids Symp Ser (Oxf); 2004; (48):93-4. PubMed ID: 17150494.
    Abstract:
    A new strategy for the detection of a single base alteration utilizing the fluorescence quenching by guanine base is described. We have devised a novel base-discrimination fluorescent (BDF) nucleoside, PyT, which contains pyrene carboxamide fluorophore at sugar 4' position. PyT-containing oligodeoxynucleotides (ODNs) exhibit an intense fluorescence only when PyT forms a complementary base pair with adenine.
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