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  • Title: Precisely controlled intracellular delivery of DNA-peptide conjugates.
    Author: Kubo T, Kanno K, Rumiana B, Ohba H, Fujii M.
    Journal: Nucleic Acids Symp Ser (Oxf); 2004; (48):99-100. PubMed ID: 17150497.
    Abstract:
    Precisely controlled intracellular delivery of oligonucleotides was achieved by conjugation with signal peptides and amphiphilic designed peptides. Localization in the cellular nucleus was accelerated by nuclear localizing signals derived from naturally occurring viral proteins and arginine rich designed peptides, and cytoplasmic localization was enhanced by nuclear export signals and membrane fusion peptides.
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