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  • Title: Novel modified purine bases and nucleosides: new methodologies of synthesis and biological activity.
    Author: Hocek M.
    Journal: Nucleic Acids Symp Ser (Oxf); 2005; (49):29-30. PubMed ID: 17150617.
    Abstract:
    Novel modified purine derivatives (bases or nucleosides) bearing C-substituents in position(s) 6, 2 and/or 8 were prepared by Pd- or Fe-catalyzed cross-coupling reactions of halopurines with organometallics. Reactions of di- and trihalopurines are regioselective and applicable to the synthesis of di- or trisubstituted purines bearing different substituents. Cross-coupling reactions of protected functionalized organometallics were used for the preparation of purines bearing functionalized C-substituents. Some of the title modified purine bases and nucleosides display cytostatic activity.
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