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  • Title: Use of abasic site-containing DNA for electrochemical SNPs detection.
    Author: Morita K, Nishizawa S, Teramae N.
    Journal: Nucleic Acids Symp Ser (Oxf); 2006; (50):91-2. PubMed ID: 17150832.
    Abstract:
    In combination with an electrode modified with an abasic site-containing DNA duplex, flavins selectively bind to thymine with a useful electrochemical response, and flavins could be successfully utilized for detection of thymine-related mutations. The abasic site provides hydrophobic microenvironments for the hydrogen bond-forming ligands can recognize the specific target base in the DNA duplex, which is detected by the difference in the electrochemical response.
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