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  • Title: Development of fluorescence-labeling method for methylcytosine with metal complexation.
    Author: Tanaka K, Tainaka K, Kamei T, Okamoto A.
    Journal: Nucleic Acids Symp Ser (Oxf); 2006; (50):135-6. PubMed ID: 17150854.
    Abstract:
    We report a methylcytosine-selective fluorescence labeling. An amino-modified bipyridine was prepared and used as an osmium ligand for methylcytosine-selective oxidation. Different fluorophores were easily incorporated to the modified methylcytosine site through an amide formation of the ligand amino group after osmium complexation.
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