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  • Title: Multiple thresholds in a model system of noisy ion channels.
    Author: Barber MJ, Ristig ML.
    Journal: Phys Rev E Stat Nonlin Soft Matter Phys; 2006 Oct; 74(4 Pt 1):041913. PubMed ID: 17155102.
    Abstract:
    Voltage-activated ion channels vary randomly between open and closed states, influenced by the membrane potential and other factors. Signal transduction is enhanced by noise in a simple ion channel model. The enhancement occurs in a finite range of signals; the range can be extended using populations of channels. The range increases more rapidly in multiple-threshold channel populations than in single-threshold populations. The diversity of ion channels may thus be present as a strategy to reduce the metabolic costs of handling a broad class of electrochemical signals.
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