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  • Title: Cyclopentanone ring-cleaved pleuromutilin derivatives.
    Author: Springer DM, Bunker A, Luh BY, Sorenson ME, Goodrich JT, Bronson JJ, DenBleyker K, Dougherty TJ, Fung-Tomc J.
    Journal: Eur J Med Chem; 2007 Jan; 42(1):109-13. PubMed ID: 17156897.
    Abstract:
    Ring-cleaved pleuromutilin derivatives comprised of a [5.3.1] bicyclic core structure have been synthesized and evaluated in vitro as antibacterial agents. Four of the compounds described were found to have MICs<or=4 microg/mL against marker strains of Streptococcus pneumoniae and Staphylococcus aureus.
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