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  • Title: HLA-G, -E and -F: allelism, function and evolution.
    Author: Moscoso J, Serrano-Vela JI, Pacheco R, Arnaiz-Villena A.
    Journal: Transpl Immunol; 2006 Dec; 17(1):61-4. PubMed ID: 17157219.
    Abstract:
    The major histocompatibility complex class I genes comprise a bunch of classical genes (A, B, C), non-classical genes (E, F and G), pseudogenes and truncated genes. MHC-E, -F and -G are now considered immune "tolerization" molecules, which not only interact with NK cells but with T lymphocyte subsets and other cells and have a role in fetus acceptation. A strong positive directional selection is acting for maintaining the observed low polymorphism on E, F and G loci in human and apes. Invariance must be important for this non-classical class I proteins function.
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