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  • Title: Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules.
    Author: Monu N, Trombetta ES.
    Journal: Curr Opin Immunol; 2007 Feb; 19(1):66-72. PubMed ID: 17157489.
    Abstract:
    Cross-presentation of exogenous proteins on MHC class I complexes contributes to the priming CD8(+) T-cell responses. However, the mechanisms by which antigen-presenting cells transfer internalized proteins to the MHC class I loading pathway are not well understood. Endocytosed proteins often appear to require proteasomal processing and transport into the endoplasmic reticulum, but the intracellular routes involved in cross-presentation remain unclear. Understanding the molecular and cellular basis of cross-presentation will illuminate novel aspects of cell physiology and might lead to improved vaccine design.
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