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  • Title: The synthesis of the internucleotide (phosphodiester) bond by a base-catalysed reaction.
    Author: von Tigerstrom R, Jahnke P, Smith M.
    Journal: Nucleic Acids Res; 1975 Oct; 2(10):1727-36. PubMed ID: 171626.
    Abstract:
    Potassium tert-butoxide in hexamethyl phosphoramide and dimethyl formamide provides an excellent catalyst for the reaction of a 3'-hydroxyl or a 5'-hydroxyl group of a nucleoside with an appropriate nucleoside phosphorofluoridate to yield the dinucleoside phosphate. This paper describes the experiments leading to the development of this reaction together with the synthesis of thymidylyl-(5' leads to 3')-thymidine (dT-dT).
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