These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The expression of nuclear factor kappa B in inflammation-induced rat corneal neovascularization.
    Author: Zhang MC, Wang Y, Yang Y.
    Journal: Ocul Immunol Inflamm; 2006 Dec; 14(6):359-65. PubMed ID: 17162607.
    Abstract:
    PURPOSE: To investigate the involvement of the nuclear-transfactor-kappa B (NF-kappa B) in the rat model of inflammation-induced corneal neovascularization (CNV). METHODS: The CNV model in Sprague-Dawley rats was induced by alkaline cauterization of the central cornea. The corneas were examined by a slit lamp microscope. NF-kappa B was assayed by Western blot. Vascular endothelial growth factor (VEGF) protein was evaluated by immunohistochemistry. VEGF mRNA levels were determined by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Morphologically, the CNV was shown on the second day after cautery. In corneas after cautery, NF-kappa B protein increased 6 hours after cautery, peaked 4 days after cautery, and decreased to near baseline by day 14. VEGF protein and mRNA increased gradually in the early stage after cautery, reached the highest level on the fourth day, and then decreased to near baseline slowly after 7 days. CONCLUSIONS: The activated NF-kappa B was up-regulated in the early stage of CNV of rat induced by cauterization, which suggests it may participate in the pathogenesis of wound healing, inflammation, and neovascularization processes in the cornea.
    [Abstract] [Full Text] [Related] [New Search]