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  • Title: [Yeast prions, mammalian amyloidoses, and the problem of proteomic networks].
    Author: Galkin AP, Mironova LN, Zhuravleva GA, Inge-Vechtomov SG.
    Journal: Genetika; 2006 Nov; 42(11):1558-70. PubMed ID: 17163073.
    Abstract:
    Prion proteins are infective amyloids and cause several neurodegenerative diseases in humans and animals. In yeasts, prions are expressed as cytoplasmic heritable determinants of a protein nature. Yeast prion [PSI], which results from a conformational rearrangement and oligomerization of translation termination factor eRF3, is used as an example to consider the structural--functional relationships in a potentially prion molecule, specifics of its evolution, and interactions with other prions, which form so-called prion networks. In addition, the review considers the results of modeling mammalian prion diseases and other amyloidoses in yeast cells. A hypothesis of proteomic networks is proposed by analogy with prion networks, involving interactions of different amyloids in mammals.
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