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  • Title: Rheumatoid nodulosis during methotrexate therapy in a patient with rheumatoid arthritis.
    Author: Matsushita I, Uzuki M, Matsuno H, Sugiyama E, Kimura T.
    Journal: Mod Rheumatol; 2006; 16(6):401-3. PubMed ID: 17165004.
    Abstract:
    We report a 62-year-old man with rheumatoid arthritis (RA) who developed nodulosis after methotrexate (MTX) treatment. The epithelioid cells of nodules were positive for matrix metalloproteinases (MMP)-2, MMP-3, MMP-9, and Ki67. The synovial tissues obtained from the same patient were negative for MMP-3, MMP-9, and Ki67. This study demonstrated that MTX-induced nodules are different from synovial tissues in terms of MMP expression, suggesting the presence of different pathologic mechanisms and differential MTX susceptibility.
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