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  • Title: A three-component tandem reductive aldol reaction catalyzed by N-heterocyclic carbene-copper complexes.
    Author: Welle A, Díez-González S, Tinant B, Nolan SP, Riant O.
    Journal: Org Lett; 2006 Dec 21; 8(26):6059-62. PubMed ID: 17165929.
    Abstract:
    [Structure: see text] An efficient catalytic system for the three-component coupling of electrophilic alkenes, aldehydes, and silane was optimized with a new family of copper N-heterocyclic carbene complexes. These catalysts do not require activation and show high activity (TOF>15,000 h-1) as well as some anti diastereoselectivity.
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