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  • Title: Steroidal saponins from Smilax china and their anti-inflammatory activities.
    Author: Shao B, Guo H, Cui Y, Ye M, Han J, Guo D.
    Journal: Phytochemistry; 2007 Mar; 68(5):623-30. PubMed ID: 17166529.
    Abstract:
    Steroidal saponins, 1, 2, 3 and 4, were isolated from the BuOH extract of Smilax china L., along with 13 known compounds, 5-17. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses and chemical evidence. In the bioassay tests, all compounds showed inhibitory effects on cyclooxygenase-2 enzyme (COX-2) activities at final concentration of 10(-5) M, and only compound 5 showed an inhibitory effect on production of TNFalpha (tumor necrosis factor alpha) in murine peritoneal macrophages at the same concentration.
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