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  • Title: [Clinical, hormonal and biochemical changes after treatment with metformin and weight reduction in women with polycystic ovary syndrome].
    Author: Pekhlivanov B, Mitkov M, Kavŭrdzhikova S.
    Journal: Akush Ginekol (Sofiia); 2006; 45(6):29-35. PubMed ID: 17168480.
    Abstract:
    AIM OF THE STUDY: to compare the clinical, hormonal and biochemical changes after the application of the two ways of influence upon insulin resistance in women with PCOS - reduction of weight and application of metformin. MATERIALS AND METHODS: It is an open, 6 months, prospective study, including 60 women with PCOS, divided in two groups. The first group (n=35) received 1700 mg metformin (M) per day. The second group (n =25) was put on a low caloric diet (1200-1400 kcal) for reduction of weight. The following anthropological and clinical parameters have been checked in the beginning and at the end of the study - weight, BMI, frequency of menstruation, waist to hip ratio, hirsutismus, defined by the Ferriman-Gallwey index. The following hormonal parameters have been studied as well - testosterone, SHBG, insulin, DHEAS, LH and FSH. FAI and HOMAIR have also been determined. RESULTS: A considerable improvement in the frequency of menstruation has been noticed in both groups, while hirsutism has been influenced positively mostly in the group, where M is applied. In group 2 the clinical improvement is directly connected with the percent of weight reduction. In group 1 the clinical changes depend on the degree of influence over insulin resistance. CONCLUSION: The higher BMI is, the more likely to expect is an effect over the menstruation cycle, due to weight reduction, than to M application or to the increase dosage of the drug. In cases of women with expressed hirsutism, it is more appropriate to apply M as a monotherapy or in combination with programs for body-weight reduction.
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