These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Errors in translation cause selective neurodegeneration.
    Author: Rochet JC.
    Journal: ACS Chem Biol; 2006 Oct 24; 1(9):562-6. PubMed ID: 17168550.
    Abstract:
    The 3D structure of a protein is determined by the unique sequence of amino acid residues comprising the polypeptide chain. Sequence changes can cause protein misfolding, a potentially toxic phenomenon implicated in various neurodegenerative disorders. In a recent paper, translational misincorporation is proposed to be a new biochemical mechanism for generating mutant proteins that misfold and kill neurons.
    [Abstract] [Full Text] [Related] [New Search]