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  • Title: Successful treatment with topical tacrolimus in four cases of discoid lupus erythematosus.
    Author: Sugano M, Shintani Y, Kobayashi K, Sakakibara N, Isomura I, Morita A.
    Journal: J Dermatol; 2006 Dec; 33(12):887-91. PubMed ID: 17169097.
    Abstract:
    Discoid lupus erythematosus (DLE), a cutaneous form of lupus erythematosus, is characterized as atrophic and scaly erythema and the lesions are often refractory to a wide range of topical or systemic therapies. Herein, we present four cases of DLE that were successfully treated with topical tacrolimus. Tacrolimus ointment (0.1%) was applied to DLE lesions twice daily and the erythematous plaques readily diminished after 4-8 weeks. Adverse effects, such as burning sensation or irritations, were not observed. These results indicate that topical tacrolimus might be an effective and alternative treatment to control DLE.
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