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  • Title: Squalene synthase inhibition: a novel target for the management of dyslipidemia.
    Author: Davidson MH.
    Journal: Curr Atheroscler Rep; 2007 Jan; 9(1):78-80. PubMed ID: 17169251.
    Abstract:
    A new class of compounds, known as squalene synthase inhibitors, has recently reached phase III clinical trials and may provide another therapeutic option for clinicians to improve risk management of low-density lipoprotein cholesterol (LDL-C). The clinical need for another LDL-C-lowering therapy is evident by the inability to achieve an LDL-C target of less than 70 mg/dL in the majority of very high-risk patients on statin monotherapy. Human clinical trial data with TAK-475, a novel and potent inhibitor of squalene synthase, have not yet been published.
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